Pharmaceutical study of antipyretic-analgesic drugs (acetaminophen)
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چکیده
منابع مشابه
COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression.
Two cyclooxygenase isozymes, COX-1 and -2, are known to catalyze the rate-limiting step of prostaglandin synthesis and are the targets of nonsteroidal antiinflammatory drugs. Here we describe a third distinct COX isozyme, COX-3, as well as two smaller COX-1-derived proteins (partial COX-1 or PCOX-1 proteins). COX-3 and one of the PCOX-1 proteins (PCOX-1a) are made from the COX-1 gene but retain...
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Despite nearing the end of the decade of pain research, the analgesic mechanisms of one of the most widely used and popular analgesics remains uncertain. Acetaminophen (APAP) (paracetamol [PARA]) has been used clinically for over a half of a century and although clinicians seem to be comfortable with its benefits, risks, and limitations, they still remain in the dark as to precisely what is pro...
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The recent introduction into the Western World of ephedrine, an alkaloid of the Chinese drug Ma Huang which has been included in the Chinese pharmacopoeia for five thousand years, has stimulated study of other obscure Chinese drugs. In order to view the field in its true perspective, a brief survey of the history of Chinese medicine, particularly in relation to the Chinese materia mnedica, is e...
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ژورنال
عنوان ژورنال: Japanese Journal of Hospital Pharmacy
سال: 1985
ISSN: 2185-9477,0389-9098
DOI: 10.5649/jjphcs1975.11.466